Biopharma’s Last Stand in TIGIT: Four Companies Betting on Differentiation and Data
SHERIDAN, WYOMING – July 8, 2025 – The TIGIT immunotherapy landscape has thinned dramatically amid a string of late-stage failures and corporate exits, yet several biopharma players remain committed to unlocking its clinical promise—driven by differentiated approaches and early signals of efficacy. AstraZeneca, Gilead, Agenus, and Mereo BioPharma are now at the forefront of this once-promising immuno-oncology frontier, recalibrating strategies in a space shaped by volatility and unmet potential.
AstraZeneca Bets Big on Dual Checkpoint Innovation
AstraZeneca’s rilvegostomig is one of the most advanced TIGIT assets in development today. The bispecific antibody is currently undergoing evaluation in ten Phase III trials across non-small cell lung cancer (NSCLC), gastric cancer, biliary tract cancer, and other solid tumors.