Combined Microneedling-Exosome Protocol Shows Melasma Improvement in Skin of Color
Louisville, Ky. – September 13, 2026 -- Induction Therapies and Collagen P.I.N., in partnership with aesthetic physician Dr. Shino Bay Aguilera, released new clinical findings on a treatment protocol combining Collagen P.I.N. microneedling with PRX8, a plant-derived exosome serum, for melasma in a patient with Fitzpatrick skin type V.
Patient shows sustained improvement after four treatments over eight weeks
The case involved a woman with longstanding facial melasma who had previously used topical hydroquinone and tranexamic acid without full resolution. She underwent four Collagen P.I.N. treatments over an eight-week period, with TRUExosomes PRX8 Plant-Exo Stimulation Serum applied after each session and daily sunscreen maintained throughout.
Visible improvement in the appearance of melasma was observed across the treatment course and persisted at the two-week follow-up after the final treatment, with no adverse reactions reported.