Research Study

Quest Study: Looser Criteria Double Primary Aldosteronism Detection

Image
Quest Study: Looser Criteria Double Primary Aldosteronism Detection

Secaucus – October 19, 2026 -- A broader set of lab criteria identified primary aldosteronism (PA) in 26.2% of 60,449 U.S. patients, twice the 13.0% flagged under the Endocrine Society's 2025 guidelines, according to a Quest Diagnostics (NYSE: DGX) study published in the journal Hypertension.

Study compares 2025 guideline cutoffs with a permissive threshold

Researchers from Quest Diagnostics, Mass General Brigham, Harvard Medical School and the University of Texas Southwestern Medical School analyzed deidentified Quest lab results. The 2025 criteria require plasma renin activity (PRA) of 1 ng/mL/h or lower, aldosterone of at least 7.5 ng/dL and an aldosterone-to-renin ratio (ARR) above 15. The permissive criteria keep the PRA limit, set aldosterone above 5 ng/dL and drop the ARR requirement.

The authors describe the 2025 guidelines as "overly restrictive," with cutoffs that capture only the most advanced cases.

Finnish Study: 40,000 m3 Hydrogen Cavern in Bedrock Costs EUR 30M

Espoo – October 19, 2026 -- A 40,000 cubic metre underground hydrogen storage facility in Finnish crystalline bedrock would cost approximately EUR 30 million and take four to five years to deliver, including planning and permitting, according to a study by VTT Technical Research Centre of Finland and the Geological Survey of Finland GTK.

The Business Finland-funded HUG project is the first comprehensive assessment of hydrogen storage requirements under Finnish conditions. Nearly twenty companies active in Finland's hydrogen economy took part.