Stockholm – October 15, 2026 -- The US National Institutes of Health (NIH) has selected SciBase Holding AB's Nevisense electrical impedance spectroscopy (EIS) technology as the primary endpoint in its THREAT study, which will test how environmental exposures affect the skin barrier in 80 healthy volunteers.
NIH and Swiss institute launch THREAT study on everyday exposures
THREAT (Testing Harms Related to Exposure to Allergenic Toxins) is led by the NIH in collaboration with the Swiss Institute of Allergy and Asthma Research (SIAF). The study design is described in an editorial in the peer-reviewed journal Allergy, titled "Exploring the Link Between Environmental Exposures and Disease via Direct Challenge."
Participants face SLS products and synthetic fibers versus 100% cotton
One group of subjects will be exposed to common skin products containing sodium lauryl sulfate (SLS) and to bedding and clothing made of synthetic fibers. The comparison group will use contactants free of SLS and apparel and linen made from natural fibers (100% cotton).
Researchers will measure and compare skin impedance as a marker of skin barrier dysfunction. Impedance devices send electrical signals at different frequencies and sense the opposition to electrical flow, which reflects the barrier status of the skin.
EIS will track barrier changes alongside molecular and microbiome markers
EIS will monitor changes in skin barrier function over time. The study will also collect molecular, microbiome and inflammatory biomarkers.
SciBase says the selection highlights EIS as an objective method for assessing skin barrier function. It cites potential applications in dermatology, cosmetic research and skin care product development.
SciBase CEO Pia Renaudin called the selection "an important step in expanding the role of our technology" in dermatology and skin health research.